LARS1

Across TCGA cell cohorts, LARS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,063 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LARS1-associated GO terms across cancer lineages are Mitochondrial DNA metabolic process, IMP biosynthetic process, and Positive regulation of chromosome organization. Each is linked with LARS1 in more than 13 cancer types. Because this analysis shows association rather than direction, both LARS1-to-partner and partner-to-LARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial DNA metabolic process grouped by LARS1-low versus LARS1-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LARS1→partner) and Y-score (partner→LARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Mitochondrial DNA metabolic process →	+0.105	+0.779	<.001	<.001	3	14
BREAST	IMP biosynthetic process →	+0.193	+0.926	<.001	<.001	3	14
SOFT_TISSUE	Positive regulation of chromosome organization →	+0.085	+0.724	<.001	<.001	3	14
OVARY	RNA surveillance →	+0.067	+0.809	<.001	.001	3	14
SOFT_TISSUE	Positive regulation of rRNA processing →	+0.119	+0.869	<.001	<.001	3	13
BONE	Subtelomeric heterochromatin formation →	+0.141	+0.718	.005	.004	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,063 associations by consensus.

Mitochondrial DNA metabolic process by LARS1 expression — LARGE_INTESTINE

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