LARS1

Across TCGA cell cohorts, LARS1 mutation is significantly associated with the RNA expression of many other genes, with 359 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LARS1-associated genes across cancer lineages are CBY1, POLR3H, and ALKBH1. Each is linked with LARS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LARS1-to-partner and partner-to-LARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBY1 grouped by LARS1-low versus LARS1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LARS1→partner) and Y-score (partner→LARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CBY1 →	+0.818	+2.482	<.001	.003	3	1
LARGE_INTESTINE	POLR3H →	+0.805	+3.169	<.001	.006	3	1
LARGE_INTESTINE	ALKBH1 →	+0.403	+3.169	.002	.009	3	1
LARGE_INTESTINE	ZC3H14 →	+0.611	+3.169	<.001	.009	3	1
LARGE_INTESTINE	PPP4R3A →	+0.494	+2.451	.001	.009	3	1
LARGE_INTESTINE	TRIP11 →	+0.656	+3.169	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 359 associations by consensus.

CBY1 by LARS1 expression — LARGE_INTESTINE

Explore this box plot interactively →