LARP7

Across TCGA patient cohorts, LARP7 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LARP7-associated genes across cancer lineages are JNK_pT183_Y185, mTOR_pS2448, and p70-S6K_pT389. Each is linked with LARP7 in more than 2 cancer types. Because this analysis shows association rather than direction, both LARP7-to-partner and partner-to-LARP7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by LARP7-low versus LARP7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LARP7→partner) and Y-score (partner→LARP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.225	-2.807	<.001	.002	3	2
UCEC	mTOR_pS2448 →	-0.164	-2.886	.002	.001	3	2
UCEC	p70-S6K_pT389 →	-0.141	-1.874	.044	.049	3	2
UCEC	PCNA →	+0.288	+3.000	<.001	<.001	2	3
UCEC	ASNS →	+0.368	+2.000	.005	.030	3	2
UCEC	c-Jun_pS73 →	-0.133	-2.797	.023	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

JNK_pT183_Y185 by LARP7 expression — UCEC

Explore this box plot interactively →