LARP7

Across TCGA cell cohorts, LARP7 mutation is significantly associated with the RNA expression of many other genes, with 36 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LARP7-associated genes across cancer lineages are TMCO5A, SPATA48, and PRM1. Each is linked with LARP7 in more than 1 cancer types. Because this analysis shows association rather than direction, both LARP7-to-partner and partner-to-LARP7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMCO5A grouped by LARP7-low versus LARP7-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LARP7→partner) and Y-score (partner→LARP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TMCO5A →	+0.030	+4.432	<.001	.003	3	2
OVARY	SPATA48 →	+0.013	+5.807	<.001	.001	3	1
OVARY	PRM1 →	+0.078	+5.196	<.001	.005	3	1
OVARY	KRTAP11-1 →	+0.139	+5.807	<.001	.001	3	1
STOMACH	CT47A6 →	+0.035	+4.285	<.001	.007	3	1
LARGE_INTESTINE	VSX2 →	+0.021	+2.672	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

TMCO5A by LARP7 expression — STOMACH

Explore this box plot interactively →