LARP4

Across TCGA pan-cancer cohorts, LARP4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated LARP4 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher LARP4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated LARP4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

PDAC, CCRCC, and UCEC are the cancer types where LARP4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.409	0.718	.003	47	view →
CCRCC	DFS	Tertile	III,IV	0.259	0.723	.002	27	view →
UCEC	OS	Tertile	III,IV	1.000	0.319	.013	20	view →
LSCC	DFS	Tertile	All	0.988	0.278	.001	12	view →
GBM	DFS	Median	All	0.294	0.447	.047	2	view →
LUAD	DFS	Median	II,III,IV	0.233	0.779	.006	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

LARP4–PDAC (OS)

Open the PDAC breakdown →