LARP4

Across TCGA patient cohorts, LARP4 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LARP4-associated genes across cancer lineages are DJ-1, GAPDH, and ACC1. Each is linked with LARP4 in more than 2 cancer types. Because this analysis shows association rather than direction, both LARP4-to-partner and partner-to-LARP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DJ-1 grouped by LARP4-low versus LARP4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LARP4→partner) and Y-score (partner→LARP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DJ-1 →	+0.130	+2.128	.022	.009	3	3
UCEC	GAPDH →	+0.521	+2.169	.004	.003	3	2
UCEC	ACC1 →	+0.248	+2.013	.045	.016	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.514	-2.000	<.001	.009	3	2
UCEC	p62 Lck ligand →	+0.344	+2.222	.001	.009	3	2
UCEC	PDCD4 →	-0.609	-2.321	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

DJ-1 by LARP4 expression — UCEC

Explore this box plot interactively →