LARGE2

Across TCGA pan-cancer cohorts, LARGE2 mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of LARGE2’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where LARGE2 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types LARGE2 is over-expressed in tumor.

LSCC and HNSC are the cancer types where LARGE2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LARGE2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	All	II,III,IV	+0.349	.011	3	view →
HNSC	All	III,IV	+0.590	.029	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

LARGE2–LSCC

Open the LSCC breakdown →