LARGE1

Across TCGA pan-cancer cohorts, LARGE1 mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of LARGE1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where LARGE1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types LARGE1 is over-expressed in tumor, although a few such as LUAD and PDAC show the opposite, repressed pattern.

LUAD and PDAC are the cancer types where LARGE1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LARGE1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	II,III,IV	−0.485	<.001	7	view →
PDAC	All	All	−0.559	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

LARGE1–LUAD

Open the LUAD breakdown →