LARGE1

Across TCGA patient cohorts, LARGE1 mutation is significantly associated with the RNA expression of many other genes, with 2,316 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LARGE1-associated genes across cancer lineages are OXSM, DCK, and FABP6. Each is linked with LARGE1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LARGE1-to-partner and partner-to-LARGE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OXSM grouped by LARGE1-low versus LARGE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LARGE1→partner) and Y-score (partner→LARGE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OXSM →	+0.290	+1.711	.001	.001	3	3
UCEC	DCK →	+0.469	+1.652	.009	.005	3	3
UCEC	FABP6 →	-0.859	-1.893	.008	.005	3	3
UCEC	MRM3 →	+0.380	+3.021	<.001	<.001	3	3
UCEC	FAM136A →	+0.385	+2.180	<.001	.001	3	3
UCEC	UFD1 →	+0.363	+2.001	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,316 associations by consensus.

OXSM by LARGE1 expression — UCEC

Explore this box plot interactively →