LARGE1

Across TCGA patient cohorts, LARGE1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LARGE1-associated genes across cancer lineages are 4E-BP1, A-Raf_pS299, and GATA6. Each is linked with LARGE1 in more than 3 cancer types. Because this analysis shows association rather than direction, both LARGE1-to-partner and partner-to-LARGE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by LARGE1-low versus LARGE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LARGE1→partner) and Y-score (partner→LARGE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.194	+1.392	.029	.019	3	4
UCEC	A-Raf_pS299 →	-0.112	-1.392	.004	.019	3	2
UCEC	GATA6 →	-0.121	-1.985	.019	.028	3	2
UCEC	JNK2 →	+0.251	+1.938	<.001	.001	3	2
UCEC	PCNA →	+0.148	+2.087	.037	.005	3	2
UCEC	PR →	-0.194	-2.321	.018	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

4E-BP1 by LARGE1 expression — UCEC

Explore this box plot interactively →