LARGE1

Across TCGA cell cohorts, LARGE1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,681 significant associations in total. BONE shows the largest number of these associations.

The most reproducible LARGE1-associated GO terms across cancer lineages are Symbiont-mediated disruption of host cellular anatomical structure, Symbiont-mediated disruption of host anatomical structure, and Regulation of glycogen metabolic process. Each is linked with LARGE1 in more than 9 cancer types. Because this analysis shows association rather than direction, both LARGE1-to-partner and partner-to-LARGE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Symbiont-mediated disruption of host cellular anatomical structure grouped by LARGE1-low versus LARGE1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LARGE1→partner) and Y-score (partner→LARGE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Symbiont-mediated disruption of host cellular anatomical structure →	+0.137	+1.660	<.001	.003	3	10
LUNG_NSCLC_LUSC	Symbiont-mediated disruption of host anatomical structure →	+0.137	+1.660	<.001	.003	3	10
BREAST	Regulation of glycogen metabolic process →	+0.074	+1.612	<.001	.008	3	10
BREAST	Urokinase plasminogen activator signaling pathway →	-0.876	-1.859	<.001	<.001	3	9
LUNG_SCLC	Negative regulation of chromosome condensation →	+0.137	+1.626	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.137	+0.815	<.001	.009	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,681 associations by consensus.

Symbiont-mediated disruption of host cellular anatomical structure by LARGE1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →