LARGE1

Across TCGA cell cohorts, LARGE1 mutation is significantly associated with the RNA expression of many other genes, with 329 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LARGE1-associated genes across cancer lineages are UCMA, DHRS7C, and OR4A47. Each is linked with LARGE1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LARGE1-to-partner and partner-to-LARGE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UCMA grouped by LARGE1-low versus LARGE1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LARGE1→partner) and Y-score (partner→LARGE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	UCMA →	+0.047	+3.926	.006	.003	3	3
PANCREAS	DHRS7C →	+0.075	+5.000	<.001	.006	3	2
LUNG_NSCLC_LUAD	OR4A47 →	+0.018	+5.228	<.001	.005	3	2
PANCREAS	CRYBB1 →	+0.022	+5.000	<.001	.006	3	1
CNS	FHL5 →	+0.015	+3.459	<.001	.006	3	1
CNS	ATP1A4 →	+0.788	+3.146	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 329 associations by consensus.

UCMA by LARGE1 expression — BLOOD_Leukemia

Explore this box plot interactively →