LAPTM5

Across TCGA patient cohorts, LAPTM5 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAPTM5-associated genes across cancer lineages are 14-3-3_beta, Heregulin, and N-Cadherin. Each is linked with LAPTM5 in more than 1 cancer types. Because this analysis shows association rather than direction, both LAPTM5-to-partner and partner-to-LAPTM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by LAPTM5-low versus LAPTM5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAPTM5→partner) and Y-score (partner→LAPTM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.143	-3.308	.006	.010	3	1
UCEC	Heregulin →	-0.140	-3.169	.030	.019	3	1
UCEC	N-Cadherin →	-0.316	-2.990	.004	.036	3	1
UCEC	p27_pT157 →	-0.065	-2.960	.032	.036	3	1
UCEC	p90 RSK →	+0.218	+3.009	.029	.019	3	1
UCEC	PEA-15_pS116 →	-0.406	-3.321	.027	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

14-3-3_beta by LAPTM5 expression — UCEC

Explore this box plot interactively →