LAPTM4B

Across TCGA pan-cancer cohorts, LAPTM4B Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated LAPTM4B data layer compared with 24 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher LAPTM4B Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated LAPTM4B expression acts as an unfavorable survival marker.

KIRP and PRAD are the cancer types where LAPTM4B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.178	0.867	<.001	6	view →
PRAD	DFS	Median	All	0.160	0.886	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

LAPTM4B–KIRP (DFS)

Open the KIRP breakdown →