LAP3

Across TCGA patient cohorts, LAP3 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAP3-associated genes across cancer lineages are MEK1, VHL, and 14-3-3_beta. Each is linked with LAP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LAP3-to-partner and partner-to-LAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by LAP3-low versus LAP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAP3→partner) and Y-score (partner→LAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.294	+2.459	.032	.018	3	2
UCEC	VHL →	-0.775	-1.584	.002	.034	3	2
UCEC	14-3-3_beta →	-0.109	-2.156	.003	.003	3	1
UCEC	EGFR_pY1068 →	-0.307	-2.584	.001	.010	3	1
UCEC	eIF4E →	+0.214	+2.662	.006	<.001	3	1
UCEC	A-Raf_pS299 →	-0.136	-2.115	.002	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

MEK1 by LAP3 expression — UCEC

Explore this box plot interactively →