LAP3

Across TCGA cell cohorts, LAP3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,472 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible LAP3-associated GO terms across cancer lineages are Positive regulation of aggrephagy, Regulation of aggrephagy, and Positive regulation of CAMKK-AMPK signaling cascade. Each is linked with LAP3 in more than 12 cancer types. Because this analysis shows association rather than direction, both LAP3-to-partner and partner-to-LAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of aggrephagy grouped by LAP3-low versus LAP3-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LAP3→partner) and Y-score (partner→LAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Positive regulation of aggrephagy →	+0.187	+0.948	<.001	<.001	3	13
LARGE_INTESTINE	Regulation of aggrephagy →	+0.135	+0.498	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Positive regulation of CAMKK-AMPK signaling cascade →	+0.541	+0.780	.002	.004	3	10
BREAST	Positive regulation of chromosome condensation →	+0.230	+1.026	<.001	<.001	3	10
BREAST	Negative regulation of cell cycle phase transition →	+0.076	+1.094	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Mitotic G2 DNA damage checkpoint signaling →	+0.079	+1.063	.004	.006	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,472 associations by consensus.

Positive regulation of aggrephagy by LAP3 expression — LARGE_INTESTINE

Explore this box plot interactively →