LAP3

Across TCGA cell cohorts, LAP3 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible LAP3-associated genes across cancer lineages are C20orf85, USP17L11, and OR4D5. Each is linked with LAP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LAP3-to-partner and partner-to-LAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C20orf85 grouped by LAP3-low versus LAP3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAP3→partner) and Y-score (partner→LAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C20orf85 →	+0.056	+5.969	<.001	.001	3	2
LUNG_NSCLC_LUAD	USP17L11 →	+0.077	+3.734	<.001	.006	3	2
LUNG_NSCLC_LUAD	OR4D5 →	+0.011	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR6T1 →	+0.031	+4.472	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR10S1 →	+0.160	+4.215	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR1D4 →	+0.031	+4.078	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

C20orf85 by LAP3 expression — BLOOD_Leukemia

Explore this box plot interactively →