LANCL3

Across TCGA patient cohorts, LANCL3 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LANCL3-associated genes across cancer lineages are ATM, eEF2, and eIF4E. Each is linked with LANCL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LANCL3-to-partner and partner-to-LANCL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by LANCL3-low versus LANCL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LANCL3→partner) and Y-score (partner→LANCL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.387	-1.700	.044	.044	3	2
UCEC	eEF2 →	+0.370	+3.169	.014	.019	3	1
UCEC	eIF4E →	+0.184	+2.820	.039	.035	3	1
UCEC	eIF4G →	+0.286	+1.700	.029	.044	3	1
UCEC	A-Raf_pS299 →	-0.104	-3.000	.039	.036	3	1
UCEC	ERK2 →	+0.202	+2.459	.013	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

ATM by LANCL3 expression — UCEC

Explore this box plot interactively →