LANCL3

Across TCGA cell cohorts, LANCL3 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LANCL3-associated genes across cancer lineages are SPRR1A, CST9, and MT1HL1. Each is linked with LANCL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LANCL3-to-partner and partner-to-LANCL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPRR1A grouped by LANCL3-low versus LANCL3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LANCL3→partner) and Y-score (partner→LANCL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SPRR1A →	+0.287	+5.201	<.001	.006	3	1
BLOOD_Leukemia	CST9 →	+0.012	+5.201	<.001	.006	3	1
BLOOD_Leukemia	MT1HL1 →	+0.326	+4.922	<.001	.009	3	1
BLOOD_Lymphoma	OR2T12 →	+0.013	+5.643	<.001	.002	3	1
OVARY	UBTFL1 →	+0.156	+5.807	<.001	.001	3	1
LUNG_NSCLC_LUAD	CCDC195 →	+0.034	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

SPRR1A by LANCL3 expression — BLOOD_Leukemia

Explore this box plot interactively →