LANCL1

Across TCGA patient cohorts, LANCL1 mutation is significantly associated with the RNA expression of many other genes, with 2,642 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LANCL1-associated genes across cancer lineages are TXNRD1, INPP5F, and IGHV4-28. Each is linked with LANCL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LANCL1-to-partner and partner-to-LANCL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TXNRD1 grouped by LANCL1-low versus LANCL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LANCL1→partner) and Y-score (partner→LANCL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TXNRD1 →	+0.796	+2.928	.003	.001	3	2
UCEC	INPP5F →	+0.444	+2.906	.008	.002	3	2
UCEC	IGHV4-28 →	+1.681	+3.700	<.001	.001	3	2
UCEC	ZNF106 →	+0.657	+3.708	<.001	<.001	3	2
UCEC	PMS2 →	+0.584	+2.906	.001	.002	3	2
UCEC	ZCCHC9 →	+0.500	+2.917	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,642 associations by consensus.

TXNRD1 by LANCL1 expression — UCEC

Explore this box plot interactively →