LANCL1

Across TCGA patient cohorts, LANCL1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LANCL1-associated genes across cancer lineages are ATM, EGFR_pY1068, and eIF4E. Each is linked with LANCL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LANCL1-to-partner and partner-to-LANCL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by LANCL1-low versus LANCL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LANCL1→partner) and Y-score (partner→LANCL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.561	-2.115	.004	.019	3	2
UCEC	EGFR_pY1068 →	-0.236	-2.807	.031	.003	3	1
UCEC	eIF4E →	+0.195	+2.115	.034	.019	2	2
UCEC	ERK2 →	+0.256	+2.115	.002	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.188	-2.794	.010	.003	3	1
UCEC	P-Cadherin →	-0.131	-2.999	.037	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

ATM by LANCL1 expression — UCEC

Explore this box plot interactively →