LAMTOR1

Across TCGA patient cohorts, LAMTOR1 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAMTOR1-associated genes across cancer lineages are Heregulin, MEK1, and p70-S6K. Each is linked with LAMTOR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LAMTOR1-to-partner and partner-to-LAMTOR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heregulin grouped by LAMTOR1-low versus LAMTOR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMTOR1→partner) and Y-score (partner→LAMTOR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Heregulin →	-0.142	-2.321	.022	.035	3	1
UCEC	MEK1 →	+0.396	+3.459	.031	.005	3	1
UCEC	p70-S6K →	+0.202	+2.348	.037	.019	3	1
UCEC	Caspase-7-cleavedD198 →	+0.860	+3.019	.003	.019	3	1
UCEC	Cyclin-B1 →	+0.651	+2.321	.020	.035	3	1
UCEC	PDCD4 →	-0.611	-2.321	.009	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Heregulin by LAMTOR1 expression — UCEC

Explore this box plot interactively →