LAMP5

Across TCGA patient cohorts, LAMP5 mutation is significantly associated with the RNA expression of many other genes, with 2,109 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAMP5-associated genes across cancer lineages are KCNIP2-AS1, FAF1, and XRCC2. Each is linked with LAMP5 in more than 3 cancer types. Because this analysis shows association rather than direction, both LAMP5-to-partner and partner-to-LAMP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNIP2-AS1 grouped by LAMP5-low versus LAMP5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMP5→partner) and Y-score (partner→LAMP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KCNIP2-AS1 →	+0.353	+3.592	<.001	.001	3	4
LUAD	FAF1 →	+0.451	+3.366	.001	.004	3	3
UCEC	XRCC2 →	+0.782	+3.823	<.001	<.001	3	3
UCEC	WDHD1 →	+0.814	+3.108	<.001	<.001	3	3
UCEC	GAN →	+0.412	+3.470	.002	.002	3	3
UCEC	MYO19 →	+0.527	+3.650	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,109 associations by consensus.

KCNIP2-AS1 by LAMP5 expression — UCEC

Explore this box plot interactively →