LAMP5

Across TCGA patient cohorts, LAMP5 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAMP5-associated genes across cancer lineages are SF2, Cyclin-B1, and GATA3. Each is linked with LAMP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both LAMP5-to-partner and partner-to-LAMP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SF2 grouped by LAMP5-low versus LAMP5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMP5→partner) and Y-score (partner→LAMP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SF2 →	+0.144	+1.770	.004	.046	3	2
SKCM	Cyclin-B1 →	+0.425	+3.584	.004	.002	3	2
SKCM	GATA3 →	-0.203	-1.502	.003	.028	3	1
SKCM	LKB1 →	-0.104	-1.700	.013	.038	3	1
SKCM	Myosin-IIa_pS1943 →	-0.213	-1.485	.039	.028	3	1
SKCM	Stathmin →	+0.218	+2.140	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

SF2 by LAMP5 expression — SKCM

Explore this box plot interactively →