LAMP5

Across TCGA cell cohorts, LAMP5 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,402 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LAMP5-associated GO terms across cancer lineages are Regulation of syncytium formation by plasma membrane fusion, Negative regulation of myoblast fusion, and Negative regulation of syncytium formation by plasma membrane fusion. Each is linked with LAMP5 in more than 8 cancer types. Because this analysis shows association rather than direction, both LAMP5-to-partner and partner-to-LAMP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of syncytium formation by plasma membrane fusion grouped by LAMP5-low versus LAMP5-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMP5→partner) and Y-score (partner→LAMP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of syncytium formation by plasma membrane fusion →	+0.098	+0.153	.001	.002	3	9
KIDNEY	Negative regulation of myoblast fusion →	+0.094	+0.145	.001	.003	3	6
KIDNEY	Negative regulation of syncytium formation by plasma membrane fusion →	+0.115	+0.164	<.001	.005	3	6
KIDNEY	Process utilizing autophagic mechanism →	+0.065	+0.159	.004	.006	3	5
KIDNEY	Autophagy →	+0.065	+0.159	.004	.006	3	5
UPPER_AERODIGESTIVE_TRACT	Vesicle-mediated transport to the plasma membrane →	+0.068	+0.030	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,402 associations by consensus.

Regulation of syncytium formation by plasma membrane fusion by LAMP5 expression — KIDNEY

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