LAMP5

Across TCGA cell cohorts, LAMP5 mutation is significantly associated with the mutation status of many other genes, with 257 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible LAMP5-associated genes across cancer lineages are TMEM151A, OCM2, and ENOPH1. Each is linked with LAMP5 in more than 2 cancer types. Because this analysis shows association rather than direction, both LAMP5-to-partner and partner-to-LAMP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM151A grouped by LAMP5-low versus LAMP5-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMP5→partner) and Y-score (partner→LAMP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TMEM151A →	+4.000	+4.303	.001	.001	1	3
LARGE_INTESTINE	OCM2 →	+5.087	+4.523	.006	.006	1	2
LARGE_INTESTINE	ENOPH1 →	+5.087	+4.523	.006	.006	1	2
LARGE_INTESTINE	RILPL2 →	+5.087	+4.523	.006	.006	1	2
LARGE_INTESTINE	ARMC12 →	+5.087	+4.523	.006	.006	1	2
LARGE_INTESTINE	KCNV1 →	+4.087	+5.044	.001	.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 257 associations by consensus.

TMEM151A by LAMP5 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →