LAMP3

Across TCGA pan-cancer cohorts, LAMP3 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated LAMP3 data layer compared with 26 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher LAMP3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated LAMP3 expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

MESO, HNSC, and GBM are the cancer types where LAMP3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	III,IV	0.098	0.579	.001	36	view →
HNSC	OS	Median	II,III,IV	0.164	0.672	.001	36	view →
GBM	OS	Median	All	0.005	0.416	<.001	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SKCM	OS	Median	All	0.583	0.790	.021	5	view →
BLCA	DFS	Median	III,IV	1.000	0.429	.035	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

LAMP3–MESO (OS)

Open the MESO breakdown →