LAMP2

Across TCGA pan-cancer cohorts, LAMP2 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated LAMP2 data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher LAMP2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated LAMP2 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

OV, GBM, and PDAC are the cancer types where LAMP2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Median	All	0.592	1.000	.002	16	view →
GBM	OS	Median	All	0.737	0.968	.001	14	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	9	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	4	view →
LSCC	DFS	Quartile	II,III,IV	0.490	0.914	.011	3	view →
UCEC	DFS	Median	All	0.857	0.948	.026	2	view →
CCRCC	DFS	Tertile	II,III,IV	0.503	0.815	.033	1	view →
HNSC	DFS	Tertile	IV	0.818	0.539	.027	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

LAMP2–OV (DFS)

Open the OV breakdown →