LAMP2

Across TCGA patient cohorts, LAMP2 mutation is significantly associated with the RNA expression of many other genes, with 4,470 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAMP2-associated genes across cancer lineages are RNA5SP113, GCAT, and HACL1. Each is linked with LAMP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LAMP2-to-partner and partner-to-LAMP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP113 grouped by LAMP2-low versus LAMP2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMP2→partner) and Y-score (partner→LAMP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNA5SP113 →	+0.201	+4.711	<.001	.004	3	2
UCEC	GCAT →	+0.418	+2.983	.005	<.001	3	2
UCEC	HACL1 →	+0.396	+2.643	<.001	<.001	3	2
UCEC	TUBG1 →	+0.690	+2.290	<.001	<.001	3	2
UCEC	HEXIM2 →	+0.423	+2.280	<.001	<.001	3	2
UCEC	NCAPH2 →	+0.600	+2.847	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,470 associations by consensus.

RNA5SP113 by LAMP2 expression — BRCA

Explore this box plot interactively →