LAMP2

Across TCGA patient cohorts, LAMP2 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAMP2-associated genes across cancer lineages are 14-3-3_beta, Shc_pY317, and ERK2. Each is linked with LAMP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LAMP2-to-partner and partner-to-LAMP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by LAMP2-low versus LAMP2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMP2→partner) and Y-score (partner→LAMP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	14-3-3_beta →	-0.231	-2.974	.029	.036	3	2
COAD	Shc_pY317 →	-0.219	-2.987	.011	.035	3	2
UCEC	ERK2 →	+0.215	+2.502	<.001	.001	3	2
UCEC	eIF4E →	+0.141	+1.473	.028	.006	3	1
UCEC	A-Raf_pS299 →	-0.101	-1.584	.005	.017	3	1
UCEC	GATA6 →	-0.162	-2.792	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

14-3-3_beta by LAMP2 expression — COAD

Explore this box plot interactively →