Across TCGA pan-cancer cohorts, LAMP1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated LAMP1 data layer compared with 18 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher LAMP1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated LAMP1 expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

BLCA, PRAD, and SKCM are the cancer types where LAMP1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Median	III,IV	1.000	0.270	.028	7	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SKCM	OS	Median	III,IV	0.216	0.721	.001	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: LAMP1 tumor-vs-normal RNA expression · all LAMP1 data types