Across TCGA patient cohorts, LAMP1 protein abundance is significantly associated with the RNA expression of many other genes, with 6,781 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LAMP1-associated genes across cancer lineages are TMCO3, RENBP, and TYROBP. Each is linked with LAMP1 in more than 4 cancer types. Because this analysis shows association rather than direction, both LAMP1-to-partner and partner-to-LAMP1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMP1→partner) and Y-score (partner→LAMP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TMCO3 →	+0.822	+0.280	<.001	<.001	3	5
GBM	RENBP →	+0.577	+0.374	.004	<.001	3	4
GBM	TYROBP →	+0.611	+0.253	<.001	<.001	3	4
GBM	AKAP7 →	-0.661	-0.233	<.001	.008	3	4
GBM	NPC2 →	+0.653	+0.265	<.001	<.001	3	4
BRCA	TM9SF2 →	+0.523	+0.258	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,781 associations by consensus.

Exploration

LAMP1 survival (RNA) · tumor vs normal (RNA) · all LAMP1 data types