Across TCGA patient cohorts, LAMP1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAMP1-associated genes across cancer lineages are Ku80, p62 Lck ligand, and PDCD4. Each is linked with LAMP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LAMP1-to-partner and partner-to-LAMP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMP1→partner) and Y-score (partner→LAMP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.264	+2.179	.020	.034	3	1
UCEC	p62 Lck ligand →	+0.371	+3.584	.018	.002	3	1
UCEC	PDCD4 →	-0.693	-3.584	.002	.002	3	1
UCEC	TIGAR →	+0.163	+3.611	.027	.001	3	1
UCEC	Caspase-8 →	-0.250	-3.169	.039	.019	2	1
UCEC	4E-BP1 →	+0.425	+3.029	.001	.018	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

LAMP1 survival (RNA) · tumor vs normal (RNA) · all LAMP1 data types