LAMC3

Across TCGA patient cohorts, LAMC3 protein abundance is significantly associated with the RNA expression of many other genes, with 7,400 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible LAMC3-associated genes across cancer lineages are EDNRB, ARHGAP6, and GUCY1A2. Each is linked with LAMC3 in more than 4 cancer types. Because this analysis shows association rather than direction, both LAMC3-to-partner and partner-to-LAMC3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LAMC3 versus EDNRB in UCEC, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMC3→partner) and Y-score (partner→LAMC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EDNRB →	+0.930	+0.875	<.001	<.001	3	5
BRCA	ARHGAP6 →	+0.752	+1.008	.005	.003	3	5
UCEC	GUCY1A2 →	+1.440	+0.580	<.001	<.001	3	5
BRCA	FHL5 →	+1.145	+1.132	<.001	.001	3	4
CCRCC	C7 →	+2.358	+0.901	<.001	<.001	3	4
BRCA	F10 →	+0.669	+1.191	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,400 associations by consensus.

LAMC3 vs EDNRB — UCEC

Explore this scatter interactively →