LAMC3

Across TCGA patient cohorts, LAMC3 mutation is significantly associated with the RNA expression of many other genes, with 6,027 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAMC3-associated genes across cancer lineages are TIMM44, MRPL19, and TTC19. Each is linked with LAMC3 in more than 3 cancer types. Because this analysis shows association rather than direction, both LAMC3-to-partner and partner-to-LAMC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIMM44 grouped by LAMC3-low versus LAMC3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMC3→partner) and Y-score (partner→LAMC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TIMM44 →	+0.403	+3.176	.001	<.001	3	4
STAD	MRPL19 →	+0.514	+2.923	<.001	<.001	3	4
UCEC	TTC19 →	+0.468	+1.440	<.001	<.001	3	4
LUSC	GUSBP16 →	+0.153	+2.622	<.001	.005	3	4
UCEC	RPL23AP82 →	+0.443	+2.081	<.001	<.001	3	4
STAD	ZNF121 →	+0.442	+3.471	.007	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,027 associations by consensus.

TIMM44 by LAMC3 expression — SKCM

Explore this box plot interactively →