LAMC3

Across TCGA patient cohorts, LAMC3 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAMC3-associated genes across cancer lineages are Caspase-7-cleavedD198, Cyclin-B1, and ERK2. Each is linked with LAMC3 in more than 4 cancer types. Because this analysis shows association rather than direction, both LAMC3-to-partner and partner-to-LAMC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by LAMC3-low versus LAMC3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMC3→partner) and Y-score (partner→LAMC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.009	+2.717	<.001	.002	3	5
UCEC	Cyclin-B1 →	+0.579	+1.544	<.001	<.001	3	4
UCEC	ERK2 →	+0.172	+1.432	<.001	.004	3	4
STAD	eEF2 →	+0.369	+3.321	.002	.009	2	4
STAD	EGFR_pY1068 →	-0.339	-3.321	.030	.009	3	3
STAD	4E-BP1 →	+0.393	+3.584	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

Caspase-7-cleavedD198 by LAMC3 expression — COAD

Explore this box plot interactively →