LAMC3

Across TCGA cell cohorts, LAMC3 mutation is significantly associated with the RNA expression of many other genes, with 275 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LAMC3-associated genes across cancer lineages are AFG1L, PADI6, and KRTAP2-4. Each is linked with LAMC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LAMC3-to-partner and partner-to-LAMC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AFG1L grouped by LAMC3-low versus LAMC3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMC3→partner) and Y-score (partner→LAMC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	AFG1L →	+0.508	+3.364	.001	.002	3	2
SKIN	PADI6 →	+0.018	+2.144	<.001	.008	3	2
LUNG_SCLC	KRTAP2-4 →	+0.024	+3.169	<.001	.005	3	2
LARGE_INTESTINE	TXNDC17 →	+0.599	+3.252	.002	.002	3	2
LARGE_INTESTINE	FAM86B2 →	+0.661	+1.628	<.001	.007	3	2
LARGE_INTESTINE	EPG5 →	+0.608	+3.169	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 275 associations by consensus.

AFG1L by LAMC3 expression — SKIN

Explore this box plot interactively →