LAMC2

Across TCGA cell cohorts, LAMC2 mutation is significantly associated with the RNA expression of many other genes, with 859 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LAMC2-associated genes across cancer lineages are FBXW10, NR2E3, and MED23. Each is linked with LAMC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both LAMC2-to-partner and partner-to-LAMC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FBXW10 grouped by LAMC2-low versus LAMC2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMC2→partner) and Y-score (partner→LAMC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FBXW10 →	+0.209	+3.491	<.001	.004	3	3
SKIN	NR2E3 →	+0.247	+3.584	<.001	.001	3	2
LARGE_INTESTINE	MED23 →	+0.580	+2.451	.001	.009	3	2
LARGE_INTESTINE	SEC24B →	+0.745	+3.502	<.001	.001	3	2
LARGE_INTESTINE	LIMD1 →	+0.626	+3.067	.003	.009	3	2
LARGE_INTESTINE	SASS6 →	+0.626	+3.321	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 859 associations by consensus.

FBXW10 by LAMC2 expression — LARGE_INTESTINE

Explore this box plot interactively →