Across TCGA patient cohorts, LAMB3 mutation is significantly associated with the RNA expression of many other genes, with 3,897 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAMB3-associated genes across cancer lineages are RNU2-24P, SAAL1, and HASPIN. Each is linked with LAMB3 in more than 4 cancer types. Because this analysis shows association rather than direction, both LAMB3-to-partner and partner-to-LAMB3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMB3→partner) and Y-score (partner→LAMB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU2-24P →	+0.084	+1.558	.005	.003	3	5
STAD	SAAL1 →	+0.631	+3.717	<.001	<.001	3	4
UCEC	HASPIN →	+0.734	+2.099	<.001	<.001	3	4
UCEC	DAZAP1 →	+0.237	+1.979	.003	.003	3	4
UCEC	HAUS2 →	+0.536	+3.180	<.001	<.001	3	4
UCEC	GEMIN4 →	+0.383	+2.828	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,897 associations by consensus.

Exploration

LAMB3 survival (RNA) · tumor vs normal (RNA) · all LAMB3 data types