Across TCGA cell cohorts, LAMB3 mutation is significantly associated with the RNA expression of many other genes, with 422 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LAMB3-associated genes across cancer lineages are ELP2, INTS10, and OPALIN. Each is linked with LAMB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LAMB3-to-partner and partner-to-LAMB3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMB3→partner) and Y-score (partner→LAMB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ELP2 →	+0.620	+3.212	.002	.006	3	2
LARGE_INTESTINE	INTS10 →	+0.577	+2.628	.004	.002	3	2
BLOOD_Leukemia	OPALIN →	+0.757	+3.777	<.001	.002	3	2
LARGE_INTESTINE	PRDX3 →	+0.559	+3.169	.001	.009	3	2
LARGE_INTESTINE	FUT10 →	+0.731	+3.743	.001	<.001	3	2
LARGE_INTESTINE	MPV17L2 →	+0.382	+2.628	.008	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 422 associations by consensus.

Exploration

LAMB3 survival (RNA) · tumor vs normal (RNA) · all LAMB3 data types