LAMB2

Across TCGA patient cohorts, LAMB2 mutation is significantly associated with the RNA expression of many other genes, with 4,302 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAMB2-associated genes across cancer lineages are EMC9, PSMB6, and GOLM2. Each is linked with LAMB2 in more than 3 cancer types. Because this analysis shows association rather than direction, both LAMB2-to-partner and partner-to-LAMB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EMC9 grouped by LAMB2-low versus LAMB2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMB2→partner) and Y-score (partner→LAMB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	EMC9 →	+0.448	+2.502	<.001	.001	3	4
COAD	PSMB6 →	+0.487	+3.013	<.001	<.001	3	4
STAD	GOLM2 →	+0.426	+3.459	.001	.005	3	4
STAD	TSPY26P →	-0.731	-2.000	.001	.009	3	4
HNSC	RPSAP40 →	+0.067	+3.388	.005	.003	3	3
STAD	CNIH1 →	+0.473	+2.968	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,302 associations by consensus.

EMC9 by LAMB2 expression — STAD

Explore this box plot interactively →