LAMB2

Across TCGA patient cohorts, LAMB2 mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAMB2-associated genes across cancer lineages are GAPDH, ATM, and Caspase-7-cleavedD198. Each is linked with LAMB2 in more than 3 cancer types. Because this analysis shows association rather than direction, both LAMB2-to-partner and partner-to-LAMB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by LAMB2-low versus LAMB2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMB2→partner) and Y-score (partner→LAMB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAPDH →	+0.406	+2.008	.048	.018	3	4
COAD	ATM →	-0.462	-2.691	.003	.006	3	4
COAD	Caspase-7-cleavedD198 →	+1.104	+2.186	<.001	.032	3	3
STAD	c-Kit →	-0.306	-2.222	.011	.010	3	3
STAD	4E-BP1 →	+0.373	+2.700	.001	.005	3	3
UCEC	eEF2 →	+0.274	+1.906	.007	.014	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

GAPDH by LAMB2 expression — COAD

Explore this box plot interactively →