LAMB2

Across TCGA cell cohorts, LAMB2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,590 significant associations in total. BONE shows the largest number of these associations.

The most reproducible LAMB2-associated GO terms across cancer lineages are Regulation of basement membrane organization, Glycoprotein catabolic process, and Ascending thin limb development. Each is linked with LAMB2 in more than 12 cancer types. Because this analysis shows association rather than direction, both LAMB2-to-partner and partner-to-LAMB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of basement membrane organization grouped by LAMB2-low versus LAMB2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMB2→partner) and Y-score (partner→LAMB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of basement membrane organization →	+0.518	+2.204	.008	.002	3	13
BONE	Glycoprotein catabolic process →	+0.167	+1.985	<.001	<.001	3	11
BONE	Ascending thin limb development →	+0.427	+1.699	.002	<.001	3	11
BONE	Metanephric ascending thin limb development →	+0.427	+1.699	.002	<.001	3	11
LUNG_NSCLC_LUSC	Actin filament depolymerization →	+0.177	+1.456	<.001	.003	3	11
BONE	Retrograde transport, endosome to Golgi →	+0.069	+1.867	.002	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,590 associations by consensus.

Regulation of basement membrane organization by LAMB2 expression — LUNG_SCLC

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