LAMB2

Across TCGA cell cohorts, LAMB2 mutation is significantly associated with the RNA expression of many other genes, with 944 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LAMB2-associated genes across cancer lineages are SRR, SIRT1, and NKX2-6. Each is linked with LAMB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both LAMB2-to-partner and partner-to-LAMB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SRR grouped by LAMB2-low versus LAMB2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMB2→partner) and Y-score (partner→LAMB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SRR →	+0.866	+3.214	.007	.006	3	3
LARGE_INTESTINE	SIRT1 →	+0.735	+3.523	<.001	<.001	3	3
SOFT_TISSUE	NKX2-6 →	+1.041	+2.874	<.001	.008	3	2
SKIN	C3orf20 →	+0.038	+2.716	.005	.009	3	2
LARGE_INTESTINE	HMGXB4 →	+0.590	+2.628	<.001	.002	3	2
LARGE_INTESTINE	LANCL1 →	+0.833	+3.067	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 944 associations by consensus.

SRR by LAMB2 expression — BLOOD_Leukemia

Explore this box plot interactively →