LAMB1

Across TCGA pan-cancer cohorts, LAMB1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated LAMB1 data layer compared with 22 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher LAMB1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated LAMB1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

HNSC, LUAD, and PDAC are the cancer types where LAMB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	IV	0.611	0.857	.012	30	view →
LUAD	OS	Median	II,III,IV	0.466	0.766	.006	27	view →
PDAC	OS	Quartile	All	0.436	0.607	.016	9	view →
CCRCC	OS	Median	III,IV	0.854	0.558	.038	2	view →
LSCC	DFS	Median	All	0.634	0.782	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

LAMB1–HNSC (OS)

Open the HNSC breakdown →