LAMB1

Across TCGA cell cohorts, LAMB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,642 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible LAMB1-associated GO terms across cancer lineages are Substrate adhesion-dependent cell spreading, Regulation of basement membrane organization, and Cell-substrate adhesion. Each is linked with LAMB1 in more than 14 cancer types. Because this analysis shows association rather than direction, both LAMB1-to-partner and partner-to-LAMB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Substrate adhesion-dependent cell spreading grouped by LAMB1-low versus LAMB1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMB1→partner) and Y-score (partner→LAMB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Substrate adhesion-dependent cell spreading →	+0.159	+2.312	.002	<.001	3	15
BLOOD_Lymphoma	Regulation of basement membrane organization →	+0.992	+2.214	<.001	.001	3	14
LUNG_NSCLC_LUSC	Cell-substrate adhesion →	+0.136	+3.078	.002	<.001	3	12
STOMACH	Integrin-mediated signaling pathway →	+0.156	+2.370	<.001	.003	3	12
LARGE_INTESTINE	Regulation of receptor clustering →	+0.167	+2.004	<.001	<.001	3	12
BONE	Viral process →	+0.096	+1.631	.002	.002	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,642 associations by consensus.

Substrate adhesion-dependent cell spreading by LAMB1 expression — OESOPHAGUS

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