LAMA5

Across TCGA patient cohorts, LAMA5 mutation is significantly associated with the RNA expression of many other genes, with 9,586 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAMA5-associated genes across cancer lineages are MMS22L, MDH1, and RACGAP1. Each is linked with LAMA5 in more than 5 cancer types. Because this analysis shows association rather than direction, both LAMA5-to-partner and partner-to-LAMA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMS22L grouped by LAMA5-low versus LAMA5-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMA5→partner) and Y-score (partner→LAMA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MMS22L →	+0.328	+2.169	.005	.003	3	6
STAD	MDH1 →	+0.371	+2.647	<.001	.004	3	6
LUAD	RACGAP1 →	+0.644	+2.193	.002	.001	3	6
LUAD	E2F7 →	+0.529	+2.169	.009	.003	3	6
LUAD	BUB1 →	+0.699	+1.789	.004	.008	3	6
STAD	NDC1 →	+0.535	+2.272	.002	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,586 associations by consensus.

MMS22L by LAMA5 expression — LUAD

Explore this box plot interactively →