LAMA5

Across TCGA patient cohorts, LAMA5 mutation is significantly associated with the total protein of many other genes, with 98 significant associations in total. COAD shows the largest number of these associations.

The most reproducible LAMA5-associated genes across cancer lineages are Cyclin-B1, P-Cadherin, and Caspase-7-cleavedD198. Each is linked with LAMA5 in more than 5 cancer types. Because this analysis shows association rather than direction, both LAMA5-to-partner and partner-to-LAMA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by LAMA5-low versus LAMA5-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMA5→partner) and Y-score (partner→LAMA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Cyclin-B1 →	+0.604	+2.807	<.001	.003	3	6
COAD	P-Cadherin →	+0.129	+1.807	.007	.022	3	5
COAD	Caspase-7-cleavedD198 →	+1.167	+1.824	<.001	.001	3	4
UCEC	Shc_pY317 →	-0.150	-1.700	<.001	.001	3	4
COAD	53BP1 →	-0.423	-2.098	<.001	.015	3	4
UCEC	p27_pT198 →	+0.065	+1.392	.023	.017	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 98 associations by consensus.

Cyclin-B1 by LAMA5 expression — STAD

Explore this box plot interactively →