LAMA4

Across TCGA pan-cancer cohorts, LAMA4 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated LAMA4 data layer compared with 28 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher LAMA4 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated LAMA4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, CESC, and KIRP are the cancer types where LAMA4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.946	0.607	.001	32	view →
CESC	OS	Median	IV	0.121	0.591	.029	12	view →
KIRP	DFS	Median	All	0.218	0.771	.029	6	view →
HNSC	OS	Median	II,III,IV	0.274	0.610	.020	6	view →
LUAD	DFS	Median	All	0.644	0.819	.015	6	view →
COAD	OS	Median	III,IV	0.171	0.697	.017	4	view →
LUSC	DFS	Median	All	0.402	0.808	.002	4	view →
SARC	DFS	Median	All	0.121	0.591	.042	3	view →
SKCM	DFS	Median	II,III,IV	0.877	0.248	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

LAMA4–UCEC (DFS)

Open the UCEC breakdown →