LAMA4

Across TCGA pan-cancer cohorts, LAMA4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated LAMA4 data layer compared with 28 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher LAMA4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated LAMA4 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LUAD, PDAC, and HNSC are the cancer types where LAMA4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	II,III,IV	0.391	0.740	.005	11	view →
PDAC	OS	Tertile	III,IV	0.328	0.932	.031	3	view →
HNSC	DFS	Median	IV	0.599	0.781	.033	2	view →
LSCC	DFS	Median	II,III,IV	0.862	0.965	.030	1	view →
CCRCC	DFS	Quartile	III,IV	0.888	0.548	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

LAMA4–LUAD (OS)

Open the LUAD breakdown →